FORGe: prioritizing variants for graph genomes
نویسندگان
چکیده
منابع مشابه
Spectral Graph Forge: Graph Generation Targeting Modularity
Community structure is an important property that captures inhomogeneities common in large networks, and modularity is one of the most widely used metrics for such community structure. In this paper, we introduce a principled methodology, the Spectral Graph Forge, for generating random graphs that preserves community structure from a real network of interest, in terms of modularity. Our approac...
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BACKGROUND Prioritizing individual rare variants within associated genes or regions often consists of an ad hoc combination of statistical and biological considerations. From the statistical perspective, rare variants are often ranked using Fisher's exact p values, which can lead to different rankings of the same set of variants depending on whether 1- or 2-sided p values are used. RESULTS We...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2018
ISSN: 1474-760X
DOI: 10.1186/s13059-018-1595-x